Pii: S0960-894x(96)00599-9
نویسندگان
چکیده
Abst rac t : The 5-methyl and 14-ethoxy substituted analogues (compounds 2 4) of the 6 opioid receptor antagonist naltrindole showed similar selectivity when compared with the reference drug. Compound 2 was a 6 receptor antagonist in the mouse vas deferens preparation (MVD) exhibiting considerably higher selectivity ratios than naltrindole, while compound 4 was found to be a full and potent 8 receptor agonist in the MVD. © 1997, Elsevier Science Ltd. All rights reserved.
منابع مشابه
Pii: S0960-894x(99)00201-2
3-Arylpyrrolidines are synthesized through the coupling of N-benzyl-3(methanesulfonyloxy)pyrrolidine with diarylcuprates. Pharmacological evaluation of a series of N-substituted3-arylpyrrolidines toward several neurotransmitter receptors indicated that some of them are good ligands for serotonin 1A receptor. Particularly, N-[(N-saccharino)butyl]pyrrolidines were found to be potent and selective...
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The spiroketals containing a benzyloxymethyl moiety at the C8 position showed the most potent apoptosis-inducing activity, whereas its analogous compounds lacking any substituent at C8 or possessing ones other than the benzyloxymethyl moiety at C8 were all much less active. These results strongly suggest an important role of the benzyloxymethyl moiety linked to the C8 oxygen atom © 1999 Elsevie...
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